Nat Rev Drug Discov. 2002 Jul;1(7):551-5

Virtual screening using grid computing: the screensaver project
by W. Graham Richards, D.Sc.
Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QH, United Kingdom

[Abstract] Discovering small molecules to interact with protein targets identified by structural genomics, proteomics and bioinformatics will be a key part of future drug discovery efforts. Computational screening of druglike molecules is likely to be valuable in this respect; however, the vast number of such molecules makes the size of this task enormous. Here, we describe how massively distributed computing using screensavers has allowed databases of billions of compounds to be screened against protein targets in a matter of days.

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